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KMID : 0894520040080020077
Development & Reproduction
2004 Volume.8 No. 2 p.77 ~ p.84
Effect of DEHP Administration on Reproductive Characteristic and Blood Metabolite in Mice
¹Úµ¿Çå/Park DH
ÀåÇö¿ë/¹ÚÃá±Ù/Á¤ÈñÅÂ/±èÁ¤ÀÍ/¾çºÎ±Ù/Jang HY/Park CK/Cheong HT/Kim CI/Yang BK
Abstract
The purpose of this experiment was to determine the effects of di(2-ethylhexyl) phthalate(DEHP) on reproductive characteristic, blood hematological and chemical values in mice. The male mice were intraperitoneally injected DEHP in negative control(no treatment), positive control(corn oil, 3ml/kg B.W), 0.5, 1.0 and 10.0mg DEHP/kg B.W and the female mice were injected DEHP in control(corn oil, 3ml/kg B.W), 0.5, 1.0 and 10.0mg DEHP/kg B.W with 5 times for 15 days on 3 days interval. The administration of DEHP in male mice were not affect on body weight, epididymis, vesicular gland and coagulating gland weight. The testis weight were slightly higher in DEHP treatment groups than in control. The semen characteristics(sperm concentration, viability, motility and abnormality) of male mice were not difference in all experimental groups. The RBC, Hb, HT, MCV, MCH, MCHC0.05). The histological evaluation of testis, ovary and affevt the reproductive characteristic, blood hematological and chemical values.
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